Our Research. |
Kenpaullone is more potent (lower cisplatin IC50) in ex-vivo mouse cochlear explant assays than 4 other benchmark compounds in clinical trials
Table comparing the IC50s and highest non-toxic doses of kenpaullone and 4 other benchmark compounds in FVB cochlear explants. Dose response of kenpaullone with cisplatin, curves were fitted using GraphPad Prism, and IC50 and R2 values are shown. Mean ± S.E.M. of OHC numbers per 160 µm of middle turn cochleae
was shown for each dose. |